Mercoledì 14 Giugno
Aula "Therasia Resort"

15:30 Registrazione dei partecipanti
16:00 Cerimonia inaugurale

I Sessione: Neuroscience
Moderatori: Giuseppe Anastasi, Seyed Khosrow Tayebati, Daniele Tommasoni

16:30-17:15 Lettura Magistrale
B. Kaminska (Warsaw, Poland)
Exploring and exploiting the tumor microenvironment to reinvigorate antitumor immunity

17:15-18:00 Lettura Magistrale
L. Calzà (Bologna)
Cellular interactions in the CNS histological microdomains: toward a dynamic 3D neuroanatomy

18:00-18:45 Tavola Rotonda
Neural networks and artificial intelligence: present, past, and future
Moderatori: Fabrizio Michetti, Giuseppe Santoro, Daniele Bruschetta, C. Tacchetti (Milano)
Artificial intelligence in healthcare: from cloud to bedside

19:30 Cocktail di benvenuto "Les Sables Noirs"

Giovedì 15 Giugno
Aula "Therasia Resort"

II Sessione: Microvesicles and nanocarriers in diagnostics and therapy
Moderatori: Michela Battistelli, Luca Maria Neri, Giovanni Tuccari

9:00-9:40 M. Bonafè, G. Storci, F. De Felice, F. Ricci., S. Santi, N. Laprovitera, M. Dicataldo, N.S. Bertuccio, D. Messelodi, L. Rossini, S. De Matteis, B. Casadei, F. Vaglio, M. Ursi, F. Barbato, M. Arpinati, E. Maffini, E. Tomassini, M. Naddeo, P. Tazzari, E. Dan, B. Sinigaglia, P. Garagnani, K.M. Kwiatkowska, M. Ferracin, P.L. Zinzani, F. Bonifazi (Bologna) (Keynote speaker)
Chimeric Antigen Receptor (CAR) positive Extracellular Vesicles as in vivo biomarkers of CAR_ T cell activity

9:40-10:05 C. Pizzimenti, A. Ieni, G. Tuccari (Messina) (Invited)
Involvement of Autophagic-Related Proteins (ATGs) in Human Brain Tumours of Astrocytic Lineage

10:05-10:30 R. Agostini, E. Polidori, P. Ceccaroli, L. Graciotti, S. Maggio, M. Battistelli, F. Luchetti, S. Codenotti, G. Pocsfalvi, M. Bonafè, V. Stocchi, A. Fanzani, M. Guescini (Urbino, Ancona, Brescia, Napoli, Bologna, Roma) (Invited)
Caveolin-1 Impact on Vesicular Secretome in a Model of Rhabdomyosarcoma

10:30-11:00 Comunicazioni orali
V. Fiorentino, C. Pizzimenti, A. Ieni, M. Martini, M. Lentini, G. Fadda, G. Tuccari (Messina)

Immunohistochemical profile of primary small B-cell lymphomas of the central nervous system

A. Iaiza, A. Incocciati, S. Masciarelli, F. Palombarini, F. Liccardo, C. Tito, A. Boffi, A. Macone, A. Bonamore, F. Fazi (Roma Sapienza)
Innovative Chimeric Archaeal-Human Ferritin Delivery System in Myeloid Leukemia Cell Lines

G. Stati, F. Rossi, V. Giansante, L. Morello, S. Sancilio, R. Di Pietro (Chieti-Pescara, Venezia)
Development of a New Curcumin-Silver Nanoparticles Synthesis Method as a Promising Formulation to Test on Human Pterygium-Derived Keratinocytes

III Sessione: Histochemistry of nuclear domains
Moderatori : Lucio Cocco, Irene Faenza, Ludovico Magaudda

11:00-11:40 P. Hozak (Prague, Czech Republic) (Keynote speaker)
Nuclear phosphoinositides - new players in regulation of gene expression

11:40-12:05 E. Schena, C. Bonfini, E. Mattioli, C. Barboni, M. R. D'Apice, G. Sarli, A. Zaghini, S. Squarzoni, G. Lattanzi (Bologna, Roma Tor Vergata) (Invited)
Adipose tissue dysfunction in laminopathies and ageing

12:05-12:30 M.Y. Follo, A. De Stefano, I. Casalin, C. Finelli, A. Curti, S. Ratti, L. Manzoli, L. Cocco (Bologna) (Invited)
Nuclear inositide signaling in myelodysplastic syndromes

12:30-13:00 Comunicazioni orali
M. Battistelli, S. Salucci, E. Falcieri (Urbino, Bologna)
Nuclear behaviour in human chondrocyte during chondroptosis: comparison between in vitro and in vivo conditions

E. Guerra, M. Trerotola, A. Moschella, S. Alberti (Chieti-Pescara, Messina)
Trop-2 induces apoptosis via transcriptional activation of TRAIL, Fas/FasL, CD40/TNFRSF5

F. Koufi, I. Rusciano, G. Ramazzotti, P. Cortelli, E. Giorgio, M. Bugiani, L. Manzoli, S. Ratti (Bologna, Pavia, Amsterdam)
Autosomal dominant leukodystrophy (ADLD): are we facing an astrocytopathy?

13:00 Pranzo

14:00-15:00 Sessione Poster n.1
Moderatori : Giuseppina Rizzo, Debora Di Mauro, Simona Pergolizzi

IV Sessione: Histochemical applications in muscle biology and pathology
Moderatori : Giuseppina Cutroneo, Elisabetta Falcieri, Fabio Trimarchi

15:00-15:40 M. Zamboni, E. Zoico, S. Urbani, A. Giani (Verona) (Keynote speaker)
Adipocyte-myocyte crosstalk and muscle quality in sarcopenic obesity

15:40-16:05 M. Sandri (Padova) (Invited)
From morphology to signaling in muscle diseases

16:05-16:30 M. Sampaolesi, M. Biglietto, M. Campaner Socias, A. Dimopoulos, N. Giarratana, K. Ioannidis, V. Marini, I. Papantoniou, L. Rinvenuto, A. Serafini, A. Wang, L. Yedigaryan (Roma Sapienza, Leuven, Belgium) (Invited)
Stem cells for muscle repair and 3D pathophysiological models

16:30-17:00 Comunicazioni orali

C. Evangelisti, S. Ratti, A. Fazio, E. Mattioli, G. Lattanzi, A. Mazzotti, A. Di Martino, C. Faldini, L. Manzoli (Bologna)
Lamin A-dependent mechano-response is altered in myotubes from young and old subjects

A. Fazio, C. Evangelisti, P. Sabatelli, C. Faldini, L. Manzoli, S. Ratti
Investigation of cellular and molecular mechanisms in pericytes of patients affected by col6-related myopathies (Bologna)

M.V. Marvi, C. Evangelisti, C. Capanni, I. Rusciano, L. Manzoli, S. Ratti (Bologna)
Can prelamin A accumulation open up new perspectives for glioblastoma?

17:00-17:15 Spazio presentazione sponsor

17:30-18:30 Assemblea della Società Italiana di Istochimica

Venerdì 16 Giugno
Aula "Therasia Resort"

V Sessione: Morphogenesis and development
Moderatori: Maria De Falco, Eugenio Gaudio, Guido Macchiarelli

9:00-9:40 C. Celik-Ozenci, (Istanbul, Turkey) (Keynote speaker)
The ticking clock: circadian rhythm in pregnancy and development

9:40-10:05 P. Bovolin, A. Saraceni, E. Cottone, B. Mognetti, M.P. Gallo, G. Merlo, F. Dal Bello (Torino) (Invited)
Microplastics and associated contaminants: potential impact on cells and developing organisms

10:05-10:30 S.A. Nottola, G. Macchiarelli (Roma Sapienza) (Invited)
Ultrastructural insights in assisted reproduction: the oocyte perspective

10:30-11:00 Comunicazioni orali

L. Ceci, R. Mancinelli, A. Franchitto, L. Pannarale, P. Onori, E. Gaudio (Roma Sapienza, Foro Italico)
Long-term effects of melatonin on estrogen signaling in cholangiocytes during PSC

G.P. Lombardo, A. Alesci, R. D'Angelo, E. Messina, A. Giliberti, S. Marino, M. Aragona, E.R. Lauriano (Messina)
Immunohistochemical characterization of langerhans cells in the skin of three amphibian species

S. Salucci, A. Bartoletti Stella, A. Bavelloni, I. Versari, G.A. Mariani, S. Burattini, M. Battistelli, P. Gobbi, E. Falcieri, I. Faenza (Bologna, Urbino)
Nuclear Phospholipase C delta 4 is a crucial player in rhabdomyosarcoma cell cycle progression

VI Sessione congiunta con StemNet: Advances in stem cells biology and regenerative medicine
Moderatori: Roberta Di Pietro, Angelo Favaloro, Gianpaolo Papaccio

11:00-11:40 F. Rusconi, MC. Iachini, A. Cherubini, C. Pistoni, V. Peli, D. Tace, N. Elia, L. Lazzari (Milano Policlinico) (Keynote speaker)
Organoids as models of human diseases

11:40-12:05 A.R. Silini, M. Magatti, A. Papait, A Cargnoni, A. Masserdotti, S. De Munari, S. Farigu, P. Romele, P. Bonassi Signoroni, E. Vertua, A. Pasotti, O. Parolini (Brescia Centro Eugenia Menni, Roma Cattolica e Policlinico Gemelli) (Invited)
Mesenchymal stromal cells from the amniotic membrane of human term placenta: potent tools for regenerative medicine

12:05-12:30 R. Gramignoli (Stockholm, Sweden) (Invited)
Chimeric animals: mice with humanized livers to test drugs or evaluate novel cell and gene therapies

12:30-13:00 Comunicazioni orali
I. Casalin, A. De Stefano, A. Cappellini, A. Curti, S. Parisi, S. Paolini, C. Finelli, L. Manzoli, S. Ratti, L. Cocco, M.Y. Follo (Bologna)
Effect of Venetoclax and Azacytidine on PLCs-dependent and apoptosis pathways in hematopoietic-to-leukemic stem cells

F. Liccardo, M. Siniegocka, T. Ottone, M. Divona, S. Miglietta, G. Familiari, S.A. Nottola, V. Petrozza, L. Tamagnone, M.T. Voso, S. Masciarelli, F. Fazi (Roma Sapienza, Tor Vergata, Cattolica)
Retinoic acid and proteotoxic stress induce AML cell death overcoming bone marrow stromal cell protection

C. Lombardo, C. Loreto, S. Castorina (Catania)
Environmental exposure to fluoro-edenite fibers and its correlation with malignant mesothelioma: an immunohistochemical investigation

13:00 Pranzo

14:00-15:00 Sessione Poster n. 2
Moderatori: Serap Arbak, Carla Loreto, Fulvia Ortolani

VII Sessione: Histochemistry and electron microscopy in cell physiology and pathology
Moderatori: Sergio Castorina, Romina Mancinelli, Demetrio Milardi

15:00-15:40 S. Cinti (Ancona) (Keynote speaker)
Histochemistry and electron microscopy of the transdifferentiation of the adipose organ

15:40-16:05 G. Cenacchi (Bologna) (Invited)
From diagnostic work-up to pathogenetic mechanism: an integrate morpho-functional approach

16:05-16:30 D. Ribatti (Bari) (Invited)
The crucial role of mast cells in chronic inflammation and tumor growth

16:30-18:00 Comunicazioni orali

G. A. Basile, A. Cacciola, D. Bruschetta, F. Trimarchi, D. Di Mauro, G. Santoro, D. Milardi (Messina)
Super resolution track density imaging: bridging the gap between in vivo brain imaging and histology

A.Bonetti, M. Contin, M. Marchini, F. Ortolani (Udine)
New insight on aortic valve interstitial cell calcification as revealed by von Kossa silver reactions adapted to electron microscopy

A.Favaloro, G. Vermiglio, C. Busacca, E. Biondo, D. Labellarte, V. Randazzo, A. Migliorato, S. Cinti (Messina - Ancona)
The sarcoglycan sub-complex during transdifferentiation from white to brown adipocytes

G. Bellese, E. Tagliatti, M.C. Gagliani, S. Santamaria, P. Arnaldi, P. Falletta, P. Rusmini, M. Matteoli, P. Castagnola, K. Cortese (Genova, Milano, London, UK)
Visualizing the subcellular action of anti-HER2 therapeutics at molecular nanoscale in breast cancer cells

G. Vermiglio, D. Milardi, L. Magaudda, D. Labellarte, E. Biondo; V. Randazzo, N. Irrera, F. Squadrito (Messina)
Sarcoglycans and obesity: new possible markers?

A.Miller, R. D'Angelo, A. Mangano, G. Rizzo, D. Di Mauro, A. Fumia, F. Trimarchi, S. Pergolizzi (Messina)
Expression of TLR2 and -SMA in IBD

M. Melloni, D. Sergi, A. Passaro, L.M. Neri (Ferrara)
Effects of hyperglycaemic conditions on Akt signal transduction in breast cancer cells

C. Pizzimenti, V. Fiorentino, A. Ieni, M. Martini, M. Lentini, G. Fadda, G. Tuccari (Messina)
The role of immunohistochemistry in the diagnosis of sellar lesions mimicking pituitary neuroendocrine tumors

20:30 Cena sociale e cerimonia di consegna dei premi


Sessione Poster N. 1

Giovedì 15 Giugno
Aula "Therasia Resort"

P1.1 HISTOPATHOLOGICAL BASIS OF EXPERIMENTAL CHRONIC BANKART MODEL
S. Guzel, M. Acikel Elmas, G. Ozgun, C. Kir, S. Ozgun Bozdag, G. F. Yamak, S. Arbak (Istanbul)

P1.2 LOCALIZATION OF GLUTATHIONE S-TRANSFERASE P NUCLEAR AND INTERACTING PROPERTIES OF NRF2/KEAP1 AS BIOMARKERS OF DRUG RESISTANT HEPATOCELLULAR CARCINOMA.
D. Bartolini, A.M. Stabile, F. Gurrato, G. Lioci, A. Pistilli, A. Migni, G. Di Sante, G. Svegliati-Baroni, A. Sidoni, M. Rende, F. Galli ( Perugia)

P1.3 ARISTOLOCHIA A POTENTIAL COAUDIUVANT IN GASTRIC CANCER THERAPY
M. Battistelli, M. Micucci, S. Salucci, S. Burattini, A. Bartoletti Stella, I Versari, I. Faenza (Urbino, Bologna)

P1.4 THE EVALUATION OF TEMPOROMANDIBULAR DISORDERS IN RHEUMATOID ARTHRITIS: IMMUNOHISTOCHEMICAL STUDY
M. Runci Anastasi, A. Centofanti, A. Favaloro, L. Magaudda, G. Santoro, A. Migliorato, C., Bussacca, Cascone P (Messina, Roma)

P1.5 HISTOCHEMICAL STUDY ON ETIOPATHOGENESIS OF CONDYLAR HYPERPLASIA
M. Runci Anastasi, A. Centofanti, A. Cacciola, G.A. Basile, D. Labellarte, G. Rizzo, P. Cascone (Messina, Roma)

P1.6 ULTRASTRUCTURE EXAMINATION OF POST-MORTEM COVID-19 LUNG SPECIMENS REVEALS THAT ALVEOLAR DAMAGE IN FATAL CASES IS NOT DUE TO VIRAL REPLICATION
K. Cortese, G. Holland, L. Muller, M.C. Gagliani, E. Barisione, L. Ball, P. Pelosi, F. Grillo, L. Mastracci, R. Fiocca, M. Laue (Berlino, Genova)

P1.7 EXPRESSION OF TLR2 AND LANGERIN/CD207 IN THE HAIR CELLS OF STYELA PLICATA CORONAL ORGAN
R. D'Angelo, A. Alesci, A. Mangano, E. Messina, S. Marino, G.P. Lombardo, A. Miller, S. Pergolizzi (Messina)

P1.8 ULTRASTRUCTURAL STUDY OF EXTRACELLULAR VESICLES IN PANCREATIC DUCTAL ADENOCARCINOMA
L. Di Angelo, V. Giansante, G. Stati, L. Centurione, S. Marletta, P. Regi, R. Di Pietro (Chieti, Verona)

P1.9 A LIGHT MICROSCOPY STUDY ON SEROTONIN IMMUNOREACTIVE NEURONAL CELL BODIES AND PROCESSES IN THE HUMAN CEREBELLUM
P. Flace, D. Galletta, P. Livrea, V. Coviello, B. Veneziani, R. Mallamaci, A. Marzullo, G. Gennarini, A. Quartarone (Bari, Messina)

P1.10 IN SITU ANALYSIS OF HUMAN AMNIOTIC MEMBRANE FROM WOMEN WITH GESTATIONAL DIABETES MELLITUS
V. Giansante, G. Stati, A. Atlasova, L. Di Angelo, F. Passaretta, L. Centurione, M. Costanzi, S. Sancilio, F. D'Antonio, M. Liberati, R. Di Pietro (Chieti)


Sessione Poster N. 2

Venerdì 16 Giugno
Aula "Therasia Resort"

P2.1 POSSIBLE ROLE OF FERROPTOSIS AND AUTOPHAGY IN THE DEVELOPMENT OF CHOLESTATIC LIVER DISEASES
R. Mancinelli, L. Ceci, A. Franchitto, A. Casini, R. Vaccaro, S. Leone, G. Vivacqua, P. Onori, E. Gaudio, (Roma)

P2.2 EVOLUTIVE ADAPTATIONS IN SKIN OF GREEN WHIP SNAKE HIEROPHIS VIRIDIFLAVIUS (Lacèpède, 1789)
S. Marino, A. Fumia, A. Giliberti, D. Di Fresco, A. Alesci (Messina)

P2.3 PROTECTIVE EFFECT OF PITUITARY ADENYLATE CYCLASE-ACTIVATING POLYPEPTIDE-ADNP AXIS IN THE CORNEA
G. Maugeri, A.G. D'Amico, B. Magrì, V. D'Agata (Catania)

P2.4 IMMUNOHISTOCHEMISTRY OF NASAL CAVITY ASSOCIATED LYMPHOID TISSUE (NALT) IN THE DOLPHIN (STENELLA COERULEOALBA)
E. Messina, A. Miller, A. Mangano, M. Aragona, D. Bruschetta, A. Fumia, G.P. Lombardo, E.R. Lauriano (Messina)

P2.5 THE ROLE OF EXERCISE AND "MECHANOKINES" TO PREVENT KNEE OSTEOARTHRITIS
G. Maugeri, V. D'Agata, C. Lombardo, S. Castorina, C. Loreto, G. Musumeci (Catania)

P2.6 THE EXERCISE EFFECT ON TELOCYTES MORPHOLOGY
G. Maugeri, V. D'Agata, C. Lombardo, S. Castorina, C. Loreto, G. Musumeci (Catania)

P2.7 SYNOVIAL FLUID DERIVED EXTRACELLULAR VESICLES: A POSSIBLE ROLE IN THE PROGRESSION OF INFLAMMATION
R. Osman, E. Olivotto, M.G. Nasoni, E. Tassinari, S. Papa, M. Guescini, F. Luchetti, M. Battistelli. (Urbino, Bologna)

P2.8 NEUROPROTECTIVE AND ANTI-INFLAMMATORY EFFECTS OF EPA AND DHA ON OLFACTORY ENSHEATHING CELLS EXPOSED TO LIPOPOLY-SACCHARIDE. A PRELIMINARY IN VITRO STUDY.
R. Pellitteri, X. Pappalardo, A. Patti, C. Sanfilippo (Catania)

P2.9 PROTECTIVE ROLE OF TART CHERRY AGAINST WHITENING OF BROWN ADIPOSE TISSUE OF OBESE RATS
V. Bellitto, S. K. Tayebati, I. Martinelli, P. Roy, G. Nittari, P. Cocci, F. A. Palermo, F. Amenta, D. Tomassoni, M. G. Gabrielli. (Camerino)

P2.10 MORPHOLOGICAL STUDY OF COLONIC MUCOSA IN MICE WITH DEXTRAN SULFATE SODIUM-INDUCED COLITIS: THE IMPACT OF PROBIOTIC SUPPLEMENTATION
D. Tomassoni, M.G. Gabrielli, V. Bellitto, I. Martinelli, P. Roy, C. Salvesi, S. Silvi, A.M. Tambella, C. Miceli (Camerino)

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